Cambridge website for Synthetic Biology resources

www.synbio.org.uk

Compiled by Jim Haseloff at the University of Cambridge. SpannerPlantLogo140This site contains details of recent papers and activity in Synthetic Biology, with particular emphasis on: (i) development of standards in biology and DNA parts, (ii) microbial and (iii) plant systems, (iv) research and teaching in the field at the University of Cambridge, (v) hardware for scientific computing and instrumentation, (vi) tools for scientific productivity and collected miscellany.

Similar to the Cambridge-based Raspberry Pi and OpenLabTools initiatives, we promote the use of low cost and open source tools - in our case for use in biological engineering.

Google: Synthetic Biology news

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Meetings: Synthetic Biology

  • 04 Aug 2014
    01:00 to 01:00

    Integrative Biology-2014 is a remarkable event for scientists/experts from academia and industry nationwide to catalyze the networking between the branches of computational biology and bioinformatics and

  • 30 Aug 2014
    01:00 to 01:00

    This conference will focus on the advancement of synthetic biology, especially its application in the field of antibiotic production in filamentous fungi and actinomycete bacteria, including the implementation

  • 14 Sep 2014
    01:00 to 01:00

    This year's conference theme Systems Biology: The Fifth Element seeks to capture the multiple facets that comprise a systems understanding of life, as a single common thread that unifies seemingly different

04 Aug 19 Sep

Weather: Cambridge

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www.synbio.org.uk

Bio-Fab Ready to Distribute Building Blocks of Synthetic Life

 

Bio-Fab Ready to Distribute Building Blocks of Synthetic Life

May 2nd, 2010 by Christopher de la Torre

 

The first biological design-build facility in the world announced that it will soon be able to synthesize chemicals, fuels and new drugs by manipulating the elements necessary to make microbes. Initiated by a grant from the National Science Foundation (NSF), the facility’s product—standardized biological parts made from genetic material—will be made available to both academic and commercial users, shortening development time and lowering research costs in the process.

In its first human practices draft-for-comment report, The BioFab: International Open Facility Advancing Biotechnology (BIOFAB) asked the core question of “what is a part?” in biology. The report explores the complexity, boundaries and evolution of biological engineering, and seeks to determine what standardization might mean for the industry.

One of BioFab’s projects—and they all seem quite ambitious—aims to build thousands of biological parts needed to control genetic expression in a select number of organisms. This collection—known as “C. dog.”—will make it possible to manipulate DNA/RNA/Protein synthesis in E. coli (a bacterium) and S. cerevisiae (a budding yeast). The product, to be used to aid researchers, will be released under the terms of a legal framework that enables the free exchange and use of standard biological parts.

Founded at the end of 2009 by bioengineering assistant professor Drew Endy and UC Berkeley’s Adam Arkin, The professionally staffed public-benefit facility represents “the first significant focused investment in the development of open technology platforms underlying and supporting the next generation of biotechnology” (BioFab.org). And with generous funding from the NSF and other prominent organizations, the operation will eventually be able to shell out tens of thousands of standard biological parts each year. While such a program reeks of ethical concerns, head of BioFab’s human practices Gaymon Bennett promises that ethical issues, including safety and security, will be addressed by creating resources that will help researchers make tough decisions. The effort will also create a new legal framework in support of its burgeoning technologies.

BioFab Directors Drew Endy (left) and Adam Arkin

Synthesizing biological parts from genes may have far-reaching ethical implications, but we can’t say it’s altogether a new idea. Designer babies have long been a part of public debate, and recent advancements like MIT’s registry of standard biological parts have paved the way for initiatives like BioFab. But there’s a big difference between making biological parts and figuring out how those parts will work together.

Creating functioning interchangeable biological parts is at the heart of BioFab’s mission. Taking modern synthetic biology’s mantra that a system is an integrated set of components one step further, BioFab will attempt to define, in context, what a component is, building on the assumption that standardized ‘parts’ don’t yet exist, and that such parts are made, not discovered.

It was clear from early on in biology’s synthetic saga that DNA’s unpredictable methods of assembly would make standardization a challenge, but several years into the new millennium a proposal was made as to how restriction enzymes could isolate DNA “BioBricks” that could effectively “mix and match” with one another using complimentary strands of overhanging base pairs. While this provided a solution to putting engineered DNA components together, it couldn’t solve how to get them to work together in predictable ways. It turns out that sans context, standardized biological parts are little more than words of an indecipherable language.

Quantifying and categorizing genetic structures—both upon which genome sequencing is based—are not in themselves new goals. The present conundrum lies not in the ability to break things down into workable units, but rather in how to reverse the process and create anew using those units. Such is the driving force behind bioengineering, and now BioFab.

[Image credit: BIOFAB, Margot Hartford]
[Source: BIOFABStanford School of Medicine]

From: http://singularityhub.com/2010/05/02/bio-fab-ready-to-distribute-building-blocks-of-synthetic-life/

Research news at Cambridge University

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www.marchantia.org

Online resources, including bibliography, weblinks and posters, for work with the simple plant system, Marchantia polymorpha.

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OpenLabTools: open technology in Cambridge

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The OpenLabTools Project is a new initiative for the development of low cost and open access scientific tools at the University of Cambridge. With support from the Raspberry Pi Foundation, student projects include data acquisition, sensing, actuating, processing and 3D manufacturing, see the openlabtools.org website.

Research Studies

PhD Studentships in Cambridge

The Board of Graduate Studies manages admission of the University's graduate students. Prospective students should start here - for an introduction to the University of Cambridge, the courses we offer, how to apply for postgraduate study, how your application will be processed, and immigration and other important information.

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