www.synbio.org.uk

Synthetic Biology Resources at Cambridge

Compiled by Jim Haseloff at the University of Cambridge. SpannerPlantLogo140This site contains details of recent papers and activity in Synthetic Biology, with particular emphasis on: (i) development of standards in biology and DNA parts, (ii) microbial and (iii) plant systems, (iv) research and teaching in the field at the University of Cambridge, (v) hardware for scientific computing and instrumentation, (vi) tools for scientific productivity and collected miscellany.

Similar to the Cambridge-based Raspberry Pi and OpenLabTools initiatives, we promote the use of low cost and open source tools - in our case for use in biological engineering.

Google: synbio news

Run mouse over list to see previews, click for full article.

Twitter Feed

Recent News

IMAGE A Mitochondrial DNA Transplant Could Help Treat Hundreds Of Diseases
Thursday, 08 January 2015
For the first time ever, researchers in New Zealand have shown that mitochondrial DNA can move between cells in an animal tumor. It's an extraordinary finding that could lead to an entirely new field of synthetic biology and the treatment of hundreds of diseases. Read more... Read More...
IMAGE Impossibly imaginative food landscapes. Warning: don't look if hungry.
Thursday, 08 January 2015
" 'Processed Views,' a photography series by Barbara Ciurej and Lindsay Lochman.   From the artists:   Processed Views interprets the frontier of industrial food production: the seductive and alarming intersection of nature and technology. As we move further away from the sources of our food, we... Read More...
IMAGE This tiny button could solve the IoT’s big headache
Thursday, 08 January 2015
Controlling your digital life from your smartphone, or even by voice, is great, but there are times when it'd be a whole lot more convenient to reach out and stab a physical button. That's the idea behind Flic, crowdfunding success from late last year, and here at CES to show off what you can do... Read More...
IMAGE Intel’s “Compute Stick” is a full Windows or Linux PC in an HDMI dongle
Thursday, 08 January 2015
Andrew Cunningham The Intel Compute Stick is a full PC in an HDMI dongle. 3 more images in gallery // LAS VEGAS, NEVADA—Set-top boxes and streaming sticks are decent, cost-effective ways to turn the TV you already have into a 'smart TV,' but Intel has an intriguing new option for those of you... Read More...
IMAGE A microbe found in a grassy field appears to contain a remarkably powerful antibiotic.
Thursday, 08 January 2015
A microbe found in a grassy field appears to contain a remarkably powerful antibiotic. Called teixobactin, it kills dangerous pathogens without any observable resistance (at least not yet). Moreover, it destroys many types of drug-resistant bacteria and it's safe in mammals. Its use may be limited,... Read More...
IMAGE To Save Our Ecosystems, Will We Have to Design Synthetic Creatures?
Wednesday, 07 January 2015
To Save Our Ecosystems, Will We Have to Design Synthetic Creatures?BY LIZ STINSON   Imagine someday in the distant future, years after the ‘sixth extinction’ went from theory to undeniable reality. Our ecosystems are failing, our biodiversity is dropping like flies (at least the ones that... Read More...
Synthetic Biology Market worth $5,630.4 Million by 2018 - Major Market Players - Amyris, Inc. (U.S.), DuPont (U.S.), GenScript USA Inc. (U.S.), Intrexon Corporation (U.S.) - WhaTech
Wednesday, 07 January 2015
Synthetic Biology Market worth $5,630.4 Million by 2018 - Major Market Players - Amyris, Inc. (U.S.), DuPont (U.S.), GenScript USA Inc. (U.S.), Intrexon Corporation (U.S.) WhaTech Channel: Industrial Market Research Reports The global synthetic biology market is segmented on the basis of tools,... Read More...
IMAGE 3 Tech Giants Quietly Investing in Synthetic Biology (ADSK, INTC, MSFT)
Wednesday, 07 January 2015
3 Tech Giants Quietly Investing in Synthetic Biology By Maxx Chatsko | More Articles January 7, 2015 | Comments (0) The introduction and widespread adoption of fun new gadgets, games, and services in the last 15 years has provided billions of dollars of revenues and profits to the technology... Read More...

Featured News

Progressive promoter element combinations classify conserved orthogonal plant circadian gene expression modules.
Friday, 29 August 2014
J R Soc Interface. 2014 Oct 6;11(99) Authors: Smieszek SP, Yang H, Paccanaro A, Devlin PF Abstract We aimed to test the proposal that progressive combinations of multiple promoter elements acting in concert may be responsible for the full range of phases observed in plant circadian output genes. In order to allow reliable selection of informative phase groupings of genes for our purpose,... Read More...
Preventing T7 RNA polymerase read-through transcription - a synthetic termination signal capable of improving bioprocess stability.
Friday, 29 August 2014
ACS Synth Biol. 2014 May 14; Authors: Mairhofer J, Wittwer A, Cserjan-Puschmann M, Striedner G Abstract The phage-derived T7 RNA polymerase is the most prominent orthogonal transcriptions system used in the field of synthetic biology. However, gene expression driven by T7 RNA polymerase is prone to read-through transcription due to contextuality of the T7 terminator. The native T7 terminator has... Read More...
Direct Mutagenesis of Thousands of Genomic Targets using Microarray-derived Oligonucleotides.
Friday, 29 August 2014
ACS Synth Biol. 2014 May 23; Authors: Bonde MT, Kosuri S, Genee HJ, Sarup-Lytzen K, Church GM, Sommer MO, Wang HH Abstract Multiplex Automated Genome Engineering (MAGE) allows simultaneous mutagenesis of multiple target sites in bacterial genomes using short oligonucleotides. However, large-scale mutagenesis requires hundreds to thousands of unique oligos, which are costly to synthesize and... Read More...

Obama and Synthetic biology

 

Congress, Obama Take Sudden Interest in Synthetic Biology

Congress explicitly took up the subject of synthetic biology for the first time Thursday during a hastily convened hearing of the House Energy and Commerce Committee.

The Wired crowd has been talking about how to engineer biological machines for years, but Craig Venter’s announcement last week that he’s created a synthetic cell has drawn the attention of the very highest levels of government.

The hearing came shortly after President Barack Obama ordered a six-month review of synthetic biology by a panel of scientific stars.

The House committee members seemed primarily interested in the potential of synthetic biology to create micro-organisms that could effectively produce hydrocarbons that could be used to power the nation’s transportation system.

“Synthetic biology also has the potential to reduce our dependence on oil and to address
climate change,” said Henry Waxman, D-California, the chair of the committee. “Research is underway to develop microbes that would produce oil, giving us a renewable fuel that could be used interchangeably with gasoline without creating more global warming pollution. Research could also lead to oil-eating microbes, an application that, as the Gulf spill unfortunately demonstrates, would be extremely useful.”

The committee heard testimony from an excellent panel of scientists composed of Venter himself, Berkeley’s Jay Keasling, Stanford’s Drew Endy, and the director of the National Institute of Allergy and Infectious Diseases, Anthony Fauci.

 

Committee members did not seem overwhelmingly familiar with the state of the science, generally reading clunkily from prepared statements. The event did not have any of the sharp give-and-takes between representatives and panelists that they sometimes do.

In fact, the hearing was technically an oversight task, but it played out closer to a gee-whiz commercial for the new firms that are trying to commercialize the technology. Venter, Keasling and Endy all have ties to companies trying to make money from synthetic biological techniques.

Keasling made the smoothest transition from his scientific work, coming up with a way to produce the anti-malarial drug artemisinin in yeast, which could substantially reduce the cost of its distribution, to his sales pitch.

“Fortuitously, artemisinin is a hydrocarbon, a fundamental building block for fuel. We are
now re-engineering the artemisinin-producing microbes to produce drop-in biofuels,” he said. “That is, through advances in synthetic biology, we can engineer these same safe, reliable, industrial microorganisms to produce biofuels that will work within our existing transportation infrastructure.”

Only one witness, Gregory Kaebnick, a bioethicist at the Hastings Center, a nonprofit that studies the ethics of biotechnology, could be said to be an outside observer of the synthetic biology industry.

“I was the only one on the panel who didn’t have a vested stake in it one way or the other. I think that’s probably a mistake,” Kaebnick told Wired.com. “The president’s panel will take it up, and they’ll probably bring in more perspectives.”

Image: Venter’s blue synthetic cells
Courtesy
 Science


Read More http://www.wired.com/wiredscience/2010/05/congress-obama-synthetic-bio/#ixzz0sH71WXEl

Research news at Cambridge University

Run mouse over list to see previews, click for full article.

European Association of Students & Postdocs in Synthetic Biology (EUSynBioS)

EUSynBioSprelimLogo240The European Association of Students & Postdocs in Synthetic Biology (EUSynBioS) invites you to join its pre-launch community. The EUSynBioS initiative seeks to shape and foster a network of young researchers active the nascent scientific discipline of synthetic biology within the European Union by means of providing an integrative central resource for interaction and professional development.

Key objectives of EUSynBioS include i) the implementation of a central web platform for sharing news and opportunities relevant to members of the community as well as for academic networking, ii) the arrangement and support of events for academic exchange and professional development, iii) liaison with representatives of industry, and iv) establishment of a primary contact for collaboration and exchange with related communities of synthetic biology students and postdocs abroad.

Registering as a member is free and can be completed within 30 seconds via the following link http://www.eusynbios.org/students-and-postdocs/join Students and postdocs who register as a EUSynBioS member will be able to:
o Access a large network of young researchers in synthetic biology for academic collaboration and exchange
o Share technical resources and teaching materials
o Stay informed about relevant events such as conferences, workshops, or social outings o Browse relevant jobs in academia and industry
o Use site visits and mentoring opportunities to interact with prospective employers
o Connect with members of related communities all over the world

By registering as a member prior to the official launch of EUSynBioS, you will not only make a statement of support which will have an impact on the resources available to the community in the future; you will also be given the chance to actively shape EUSynBioS right from the start, and have an edge when applying for a position on the Steering Committee. We are looking forward to your joining us ! Christian Boehm, University of Cambridge.