Cambridge website for Synthetic Biology Resources

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Compiled by Jim Haseloff at the University of Cambridge.

This site contains details of recent papers and activity in Synthetic Biology, with particular emphasis on: (i) development of standards in biology and DNA parts, (ii) microbial and (iii) plant systems, (iv) hardware for scientific computing and instrumentation, (v) tools for scientific productivity and (vi) collected miscellany.

The site also contains details of Synthetic Biology research and teaching at the University of Cambridge, including the annual iGEM team run by Jim Ajioka, Jim Haseloff and Gos Micklem in Cambridge.

 

www.synbio.org.uk

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SynBio calendar

  • 04 Jun

    Fourth International Workshop on Bio-Design Automation (IWBDA)

    The Fourth International Workshop on Bio-Design Automation (IWBDA) at DAC will bring together researchers from the synthetic biology, systems biology, and design automation communities....

  • 06 Jun

    New Phytologist Workshop: Synthetic Biology

    The overall goal for the workshop is to bring together scientists working in the highly interdisciplinary field of synthetic biology to present cutting-edge research aligned with three...

  • 20 Jun

    GCAT Synthetic Biology Workshop

    GCAT is pleased to announce a synthetic biology faculty workshop for the summer of 2012 (June 20-22) hosted by HHMI’s Science Education Alliance (SEA). The goal of this workshop...

  • 25 Jun

    enGENEious: Evolving Life for Future Technologies

    A student and post-doc organised conference: they have invited the world's leading scientists to highlight the recent advances in microbial engineering, along with discussing the challenges...

  • 30 Jul

    BioBuilding 2012 workshop

    A week long, professional development class will prepare educators to bring biological engineering and synthetic biology into their classrooms and laboratories. The workshop will include...

  • 24 Sep

    Synthetic Biology meeting in Cambridge, UK

  • 02 Nov

    iGEM2012 World Championship Jamboree

    Finals for the international Genetically Engineered Machine Competition.

  • 26 Nov

    CSH Asia Conference: Synthetic Biology

    The 2nd CSH Asia Synthetic Biology meeting will be held at the Suzhou Dushu Lake Conference Center in Suzhou, China, located approximately 60 miles west of Shanghai.

  • 09 Jun

    Gordon Conference: Synthetic Biology

    (Re-)constructing and Re-programming Life

04 Jun - 09 Jun
20 Jun - 27 Jun
30 Jul - 28 Sep
02 Nov - 01 Dec
09 Jun - 15 Jun

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Synbio news:
2 Feb 2012

A novel method of transgene delivery into triticale plants using the Agrobacterium T-DNA-derived nano-complex.

Genetic transformation of monocotyledonous plants still presents a challenge for plant biologists and biotechnologists, since monocots are difficult to transform with Agrobacterium tumefaciens, whereas other transgenesis methods, such as gold particle-mediated transformation, result in poor transgene expression due to integration of truncated DNA molecules. We developed a novel method of transgene delivery into monocots. This method relies on the use of in vitro prepared nano-complex consisting of T-DNA, VirD2 and RecA proteins delivered to triticale microspores with the help of Tat2 cell penetrating peptide. We showed that this approach (i) allowed for single transgene copy integration events, and (ii) prevented degradation of delivered DNA, thus leading to the integration of intact copies of the transgene into the genome of triticale plants. This resulted in transgene expression in all transgenic plants regenerated from microspores transfected with full T-DNA/protein complex. This approach can easily substitute bombardment technique currently used for monocots and will be highly valuable for plant biology and biotechnology.

A novel method of transgene delivery into triticale plants using the Agrobacterium T-DNA-derived nano-complex.: "Publication Date: 2012 Jan 30 PMID: 22291201
Authors: Ziemienowicz, A. - Shim, Y. S. - Matsuoka, A. - Eudes, F. - Kovalchuk, I.
Journal: Plant Physiol

(Via Plant Physiology.)

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Instrumentation

DNA parts

Plant systems

Productivity