www.synbio.org.uk

Synthetic Biology Resources at Cambridge

Compiled by Jim Haseloff at the University of Cambridge. SpannerPlantLogo140This site contains details of recent papers and activity in Synthetic Biology, with particular emphasis on: (i) development of standards in biology and DNA parts, (ii) microbial and (iii) plant systems, (iv) research and teaching in the field at the University of Cambridge, (v) hardware for scientific computing and instrumentation, (vi) tools for scientific productivity and collected miscellany.

Similar to the Cambridge-based Raspberry Pi and OpenLabTools initiatives, we promote the use of low cost and open source tools - in our case for use in biological engineering.

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Recent News

IMAGE A Mitochondrial DNA Transplant Could Help Treat Hundreds Of Diseases
Thursday, 08 January 2015
For the first time ever, researchers in New Zealand have shown that mitochondrial DNA can move between cells in an animal tumor. It's an extraordinary finding that could lead to an entirely new field of synthetic biology and the treatment of hundreds of diseases. Read more... Read More...
IMAGE Impossibly imaginative food landscapes. Warning: don't look if hungry.
Thursday, 08 January 2015
" 'Processed Views,' a photography series by Barbara Ciurej and Lindsay Lochman.   From the artists:   Processed Views interprets the frontier of industrial food production: the seductive and alarming intersection of nature and technology. As we move further away from the sources of our food, we... Read More...
IMAGE This tiny button could solve the IoT’s big headache
Thursday, 08 January 2015
Controlling your digital life from your smartphone, or even by voice, is great, but there are times when it'd be a whole lot more convenient to reach out and stab a physical button. That's the idea behind Flic, crowdfunding success from late last year, and here at CES to show off what you can do... Read More...
IMAGE Intel’s “Compute Stick” is a full Windows or Linux PC in an HDMI dongle
Thursday, 08 January 2015
Andrew Cunningham The Intel Compute Stick is a full PC in an HDMI dongle. 3 more images in gallery // LAS VEGAS, NEVADA—Set-top boxes and streaming sticks are decent, cost-effective ways to turn the TV you already have into a 'smart TV,' but Intel has an intriguing new option for those of you... Read More...
IMAGE A microbe found in a grassy field appears to contain a remarkably powerful antibiotic.
Thursday, 08 January 2015
A microbe found in a grassy field appears to contain a remarkably powerful antibiotic. Called teixobactin, it kills dangerous pathogens without any observable resistance (at least not yet). Moreover, it destroys many types of drug-resistant bacteria and it's safe in mammals. Its use may be limited,... Read More...
IMAGE To Save Our Ecosystems, Will We Have to Design Synthetic Creatures?
Wednesday, 07 January 2015
To Save Our Ecosystems, Will We Have to Design Synthetic Creatures?BY LIZ STINSON   Imagine someday in the distant future, years after the ‘sixth extinction’ went from theory to undeniable reality. Our ecosystems are failing, our biodiversity is dropping like flies (at least the ones that... Read More...
Synthetic Biology Market worth $5,630.4 Million by 2018 - Major Market Players - Amyris, Inc. (U.S.), DuPont (U.S.), GenScript USA Inc. (U.S.), Intrexon Corporation (U.S.) - WhaTech
Wednesday, 07 January 2015
Synthetic Biology Market worth $5,630.4 Million by 2018 - Major Market Players - Amyris, Inc. (U.S.), DuPont (U.S.), GenScript USA Inc. (U.S.), Intrexon Corporation (U.S.) WhaTech Channel: Industrial Market Research Reports The global synthetic biology market is segmented on the basis of tools,... Read More...
IMAGE 3 Tech Giants Quietly Investing in Synthetic Biology (ADSK, INTC, MSFT)
Wednesday, 07 January 2015
3 Tech Giants Quietly Investing in Synthetic Biology By Maxx Chatsko | More Articles January 7, 2015 | Comments (0) The introduction and widespread adoption of fun new gadgets, games, and services in the last 15 years has provided billions of dollars of revenues and profits to the technology... Read More...

Featured News

This tiny button could solve the IoT’s big headache
Thursday, 08 January 2015
Controlling your digital life from your smartphone, or even by voice, is great, but there are times when it'd be a whole lot more convenient to reach out and stab a physical button. That's the idea behind Flic, crowdfunding success from late last year, and here at CES to show off what you can do with a tiny stick-on button, … Continue reading" 
Intel’s “Compute Stick” is a full Windows or Linux PC in an HDMI dongle
Thursday, 08 January 2015
Andrew Cunningham The Intel Compute Stick is a full PC in an HDMI dongle. 3 more images in gallery // LAS VEGAS, NEVADA—Set-top boxes and streaming sticks are decent, cost-effective ways to turn the TV you already have into a 'smart TV,' but Intel has an intriguing new option for those of you who want something a little more versatile. The Intel Compute Stick is a full Bay Trail PC complete... Read More...
Controlling a Flip-Disc Display Using Android
Thursday, 01 January 2015
There’s just something about electro-mechanical displays that enthralls most people when they see them; and while you’ll be hard pressed to find a split-flap display for cheap, you can still easily buy flip-disc displays! That’s what [Scott] did, and he’s been having a blast messing around with his and building a system to control it via his Android phone. He picked up the display from a... Read More...

Amyris cuts production target

From: ICIS Green Chemicals

I actually saw tweets last week about Amyris' announcement to scale back its 2012 farnesene "Biofene" production but I wasn't sure if I should wait further for the company's fourth quarter earnings results, which will be out on February 27, before posting this.

However, given that I will cover NatureWorks' bioplastic conference "Innovation Takes Roots" in Orlando on February 20, and the Jefferies Global CleanTech Conference on February 22 and 23, PLUS, Gevo and Solazyme will also post their quarter earnings results in the next few days, there will be lots more news piling up my draft box (Codexis' earnings result that came out on February 7 is already waiting in there...)

So let's get on with this one.

When Amyris announced its unexpected "not-so-positive"earnings guidance on late February 9, several investment firms downgraded the company such as Deutsche Bank, Morgan Stanley, Piper Jaffray, Raymond James and RW Baird. The company's shares dropped 29% to $6.93 on February 10, well below it's previous 52-week low of $8.77.

Amyris told analysts that:

  • It is scrapping its plans for its second industrial-scale production facility, which is owned by penicillin producer Antibioticos S.A. in Leon, Spain. Instead, Amyris will only complete its initial industrial-scale plant project in Piracicaba, Sao Paulo, where it has formed joint ventures with Paraiso Bioenergia and Grupo Sao Martinho. Last year, Amyris received $12.6m in financing from the Brazilian Development Bank for the Piracicaba project.

  • In conjunction with the cut, it will no longer produce 40-50 million liters of Biofene the company projected for 2012. Amyris said it has produced over 1m liters of Biofene from three contract facilities -Biomin in Piracicaba, Brazil; Antibioticos in Leon, Spain; and Tate & Lyle in Illinois, US. The company set production target at 9m liters in early 2011 and was reduced to 1-2m liters in the latter months.

  • Another in conjunction, Amyris will not be able to forecast positive cashflow this year and instead needs to raise additional equity financing. The financing is expected to close in the coming weeks, according to Amyris.

  • The company will also eliminate reporting production forecasts on its quarterly earnings, and instead will only provide production results and updates on their progress.

  • Another big change is refocusing its Biofene commercialization in higher-margin markets like polymers, cosmetics, flavors and fragrances, and branded consumer products, instead of higher-volume markets such as biofuel and base oil. Development in the biofuel/base oil areas will instead be pursued through joint ventures with partners "capable of driving these products to scale," the company said. Amyris, emphasized, however, that it is not stopping its relatively small scale biofuel production, where some of is already being used to make diesel fuel for buses in Sao Paulo (supply contract ends in 2012) and Rio de Janeiro (fleet test ends in July 2012)

"We showed conclusively that our technology does work at scale, but also learned that it takes time to translate from peak yield levels in the lab to maintaining those yields over longer operational periods in the field. Our priority is now to establish reliable production across our facilities. We need to retain flexibility in how we optimize between production volume, cost, customer demand and cash, rather than driving to deliver a predetermined production volume." - John Melo, CEO.


More information will be shared next week during Amyris' presentation at the Jefferies CleanTech conference as well as the company's quarterly financial results on February 27.

Amyris cuts production target: "

(Via ICIS Green Chemicals.)

Research news at Cambridge University

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European Association of Students & Postdocs in Synthetic Biology (EUSynBioS)

EUSynBioSprelimLogo240The European Association of Students & Postdocs in Synthetic Biology (EUSynBioS) invites you to join its pre-launch community. The EUSynBioS initiative seeks to shape and foster a network of young researchers active the nascent scientific discipline of synthetic biology within the European Union by means of providing an integrative central resource for interaction and professional development.

Key objectives of EUSynBioS include i) the implementation of a central web platform for sharing news and opportunities relevant to members of the community as well as for academic networking, ii) the arrangement and support of events for academic exchange and professional development, iii) liaison with representatives of industry, and iv) establishment of a primary contact for collaboration and exchange with related communities of synthetic biology students and postdocs abroad.

Registering as a member is free and can be completed within 30 seconds via the following link http://www.eusynbios.org/students-and-postdocs/join Students and postdocs who register as a EUSynBioS member will be able to:
o Access a large network of young researchers in synthetic biology for academic collaboration and exchange
o Share technical resources and teaching materials
o Stay informed about relevant events such as conferences, workshops, or social outings o Browse relevant jobs in academia and industry
o Use site visits and mentoring opportunities to interact with prospective employers
o Connect with members of related communities all over the world

By registering as a member prior to the official launch of EUSynBioS, you will not only make a statement of support which will have an impact on the resources available to the community in the future; you will also be given the chance to actively shape EUSynBioS right from the start, and have an edge when applying for a position on the Steering Committee. We are looking forward to your joining us ! Christian Boehm, University of Cambridge.