Quiet gene circuit more fragile than its noisy peer.
Cell. 2009 Oct 30;139(3):460-1.
Bollenbach T, Kishony R.
Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue,
Boston, MA 02115, USA.
Why is a particular architecture for a pathway chosen over seemingly equivalent
alternatives? Cağatay et al. (2009) use a synthetic biology approach to show that
fluctuations--or noise--in protein levels may play a key role in determining
which network design is selected during evolution.
Comment on:
Cell. 2009 Oct 30;139(3):512-22.