9 Jun 2009

Resecting a double-strand break

At loose ends: resecting a double-strand break.

Cell. 2009 May 29;137(5):807-10.

Bernstein KA, Rothstein R.

Columbia University Medical Center, Department of Genetics & Development, New York, NY 10032, USA.

Double-strand break (DSB) repair is critical for maintaining genomic integrity and requires the processing of the 5' DSB ends. Recent studies have shed light on the mechanism and regulation of DNA end processing during DSB repair by homologous recombination.