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Cambridge website for Synthetic Biology Resources

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Compiled by Jim Haseloff at the University of Cambridge

This site contains details of recent papers and activity in Synthetic Biology, with particular emphasis on: (i) development of standards in biology and DNA biobricks , (ii) microbial and (iii) plant systems, (iv) hardware for scientific computing and instrumentation, (v) tools for scientific productivity and (vi) collected miscellany.

The site also contains details of Synthetic Biology research and teaching at the University of Cambridge, including the annual iGEM team run by Jim AjiokaJim Haseloff and Gos Micklem in Cambridge.

Synthetic Biology Faculty position

The Department of Chemical and Biological Engineering at Colorado Sate University currently has an open tenure-track position for a scientist with synthetic biology expertise. Information regarding the application process and required application materials may be found at https://www.engr.colostate.edu/cheme/search/ 

 

Synthetic Biology worth $4.5B by 2015

GIA announces the release of a global market report on Synthetic Biology. Global Synthetic biology market is projected to exceed $4.5 billion by the year 2015. Synthetic biology is expected to provide major advances in the areas of biomedicine, biopharmaceuticals synthesis, biosecurity, energy and environment, sustainable chemical segment, and biomaterials/smart materials production. Significant investments are expected in the synthetic biology field.

San Jose, CA (Vocus) July 13, 2010 -- Synthetic biology is an emerging technology, which enables the creation of organisms from a genetic code that is not found in the natural world. The new biological research area integrates sciencewith engineering for designing and building novel biological entities, including cells, genetic circuits and enzymes, or for redesigning active biological systems and living organisms, such as bacteria.

Synthetic Biology is gaining tremendous recognition as a transformative technology that not just has the capability to address food shortage and security issues but also tackle other threats such as climate change, water deficit and energy shortages. The market would be driven by growing popularity of synthetic biology in the areas of energy and chemicals, biotechnology and pharmaceuticals, and other potential applications.

Scotland and the UK have made significant strides in the field of synthetic biology, as stated by a new report on Synthetic Biology. However, of late, the market has seen the emergence of several European and Far East countries. Synthetic biology is also gaining popularity in Japan and China. In terms of research, most of the research in synthetic biology is being pioneered by the US groups; however, a few UK universities (including Cambridge and Imperial College) are also engaged in the work. The research community in Europe is relatively slower in embracing the field. Nevertheless, the EU community possesses enormous expertise that can be tapped in order to develop a European synthetic biology programme. Scotland’s £2.5 million worth Genome Segment Assembly (GSA)programme, expected to offer tremendous opportunity to the country for gaining competitive advantage in the synthetic biology market.

Key players analyzed include Amyris Biotechnologies Inc., ATG Biosynthetics GmbH, Blue Heron Biotechnology, Inc., Chromatin Inc., DNA2.0, febit Synbio GmbH, GENEART AG, GenScript USA, Inc., Gevo Inc., LS9 Inc., Solazyme Inc., Sloning BioTechnology GmbH, Synthetic Genomics Inc., Verdezyne Inc.

For more details about this market research report, please visit – http://www.strategyr.com/Synthetic_Biology_Market_Report.asp
From: http://www.earthtimes.org/articles/press/global-industry-analysts-inc,1379787.html

 

Royal Society: Future Technologies

In the past 25 years our use of technology has increased at an unprecedented rate, affecting our way of life and how we function in society. What's next? Are we set to see more inventions that change the image of technology and the culture we live in? How will these developments affect and influence the future of society? Our expert panel gives their views and insights into their own use of technology and their hopes for the future. The panel included:

  • Sir Tim Berners-Lee FRS , inventor of the World Wide Web and Director of the World Wide Web Consortium (W3C)
  • Stephen Fry, writer, broadcaster and technophile
  • Professor Dame Wendy Hall FRS , leading computer scientist at University of Southampton
  • Dr Jim Haseloff, synthetic biologist from University of Cambridge
  • Bill Thompson, technology critic and commentator on digital culture.
  • Watch the webcast 
    http://seefurtherfestival.org/news/photographs-and-webcast-future-technologies
     
 

Synthetic Biology at the Wellcome Trust

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Synthetic Biology features in the new window display at the headquarters of the Wellcome Trust at 215 Euston Road, London.
The display features six different projects created by students, graduates and staff from the Design Interactions department at the Royal College of Art, each offering an alternative view of how science could influence our future. The purpose is not to offer predictions, but to inspire debate about the human consequences of different technological futures, both positive and negative, by asking 'What If…?'

Curated by leading London based design duo Anthony Dunne and Fiona Raby, 'What If...?' features a range of works by designers who have explored everything from clouds engineered to 'snow' ice cream, through to the social consequences of machines that could read your every emotion - and includes displays exploring the theme of Synthetic Biology by Daisy Ginsberg, James King and Michael Burton.

What if...bacteria recoloured our world? 
E. chromi: James King and Alexandra Daisy Ginsberg, 2009
For the 2009 International Genetically Engineered Machine competition (iGEM), seven Cambridge University undergraduates modified E. coli to secrete coloured pigments. These bacteria, which were named 'E. chromi', have many potential uses, including biosensors to test for pollutants in drinking water. How might the use of bacteria to produce pigments develop? What are the broader implications? The timeline considers products we might buy that use 'E. chromi', people whose livelihood might depend on it, and laws that might be needed to regulate it.

 What if...we accept co-evolution with bacteria, microbes and parasites as a healthy option? 
The Race: Michael Burton, 2007
For every human cell in the body there are ten nonhuman cells - bacteria, viruses, fungi and other microbes - living inside and on you. They are vital to many of your daily functions. 'The Race' responds to this and to human meta-genomic research to reconsider our approach to healthcare as a co-evolved organism and conglomeration of vital bacteria, microbes and parasites. The project scrutinises our inadvertent assistance of super-bugs like MRSA through the overuse of antibiotics. Instead it offers alternative enhancements, new behaviours and objects for a more symbiotic future.

What if...everyday products contained synthetically produced living components? 
The Synthetic Kingdom: A natural history of the synthetic future: Alexandra Daisy Ginsberg, 2009
How will we classify what is natural or unnatural when life is built from scratch? Synthetic biology is turning to the living kingdoms for its materials library. No more petrochemicals: instead, pick a feature from an existing organism, locate its DNA and insert into a biological chassis. Engineered life will compute, produce energy, clean up pollution, kill pathogens and even do the housework. Meanwhile, we add an extra branch to the Tree of Life. 'The Synthetic Kingdom' is part of our new nature. Biotech promises us control over nature, but living machines need controlling. Are promises of sustainability and healthiness seductive enough to accept such compromise?

Senior Curator at the Wellcome Trust, James Peto said: "It's great that there will be so much change built into the designs for the Euston Road windows this year. By next Christmas 'What If...?' will have showcased projects by 15 different students, graduates and staff from the Design Interactions course. The windows offer a great platform for asking some gently provocative questions about humanity's relationship with technology. We estimate that around 5000 people pass by them every day, on foot alone."The display will be refreshed with new designs throughout the year with the first instalment unveiled on Thursday 4 February.

From: http://www.wellcome.ac.uk/News/Media-office/Press-releases/2010/WTX058379.htm

 

Giant Plant Cells

Giant plant cells seen at University of Cambridge 800th Anniversary Finale: Confocal images of plant tissues were used by Ross Ashton, projection artist, as part of an amazing laser show. The show was part of a celebration of learning at the University - with the theme of "Transforming Tomorrow". Images spanning fields such as Astronomy, Nanotechnology and Biology were projected over the King's College Chapel, the Gibbs building and the Senate house. Pictures of the light show can be seen at http://www.flickr.com/photos/79524387@N00/sets/72157623050206293/

Original confocal images can be seen at http://www.plantsci.cam.ac.uk/Haseloff/imaging/CellArchitecture/index.html

 

Grand Prize for Cambridge iGEM2009 team

The Cambridge iGEM 2009 team presented their E. chromi project at the iGEM Jamboree at MIT. They described new BioBricks for the production of pigments in bacteria, and sensitivity tuners for the construction of new enviromental biosensors. (1st of November 2009)  
The Cambridge iGEM team was awarded the Grand Prize for the iGEM2009 Jamboree - to cap a gold medal and first prize in the Environment track. (Monday 2nd November 2009)

 

rsif_focus_cover_synbio.jpgSpecial Synthetic Biology issue by the Royal Society Interface and IET Synthetic Biology Journals.

Organised by Jim Haseloff, Jim Ajioka and Richard Kitney

This special joint issue contains a collection of articles that describe efforts to establish improved software and biological tools for the design and assembly of synthetic DNA-based programmes. 

This synthetic biology approach is arising as a result of the collision between science and engineering. It is especially appropriate that this special issue is co-sponsored by the Royal Society and the Institution of Engineering and Technology. As well as representing the twin disciplines of science and technology, the two institutions have provided strong support and guidance for the emerging field, and the collection of articles provides an insight into thinking about current challenges in the field, and prospects for future progress.

Areas covered include DNA synthesis and assembly, the design of genetic networks, microbial systems, artificial life and the ethical, social and economic implications of synthetic biology. All the contributions are free to access online - at The Royal Society Synthetic Biology Gateway.

 

Synthetic Biology Project

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Woodrow Wilson International Center for Scholars (http://www.synbioproject.org)

The Synthetic Biology Project was established as an initiative of the Foresight & Governance Program of the Woodrow Wilson International Center for Scholars. The Project aims to foster informed public and policy discourse concerning the advancement of synthetic biology – an emerging interdisciplinary field that uses advanced science and engineering to make or re-design living organisms, such as bacteria, so they can carry out specific functions. Synthetic biology involves making new genetic code, also known as DNA, which does not already exist in nature. 

synbio2cover.jpgThe Synthetic Biology Project provides independent, rigorous analysis that can inform critical decisions affecting the research, commercialization and use of synthetic biology. Its objective is to help ensure that, as synthetic biology moves forward, possible risks are minimized and benefits maximized. The Synthetic Biology Project has produced a number of informative reports about Synthetic Biology.
Trends in American & European Press Coverage of Synthetic Biology
Tracking the last five years of media coverage
New Life, Old Bottles
Examines the benefits and drawbacks of using the existing U.S. regulatory framework for biotechnology to cover the new products and processes enabled by synthetic biology.

 

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SynBio news

  • Obama and Synthetic biology   Congress, Obama Take Sudden Interest in Synthetic Biology Congress explicitly took up the subject of synthetic biology for the first time Thursday during a hastily convened hearing of the House Energy and Commerce Committee. The Wired...
  • EuroSYNBIO Projects   BBSRC, EPSRC fund £1.5M for synthetic biology projects under EuroSYNBIO Programme 19. May 2010 08:09 Four new projects, announced today, will develop biological methods that offer a new approach to antibiotic production, power generation...
  • Bio-Fab Ready to Distribute Building Blocks of Synthetic Life   Bio-Fab Ready to Distribute Building Blocks of Synthetic Life May 2nd, 2010 by Christopher de la Torre   The first biological design-build facility in the world announced that it will soon be able to synthesize chemicals,...
  • National Academies SynBio grants  National Academies' Grants to Spur Synthetic Biology  From GenomeWeb (http://www.genomeweb.com/national-academies-grants-spur-synthetic-biology)   NEW YORK (GenomeWeb News) – The National Academies' Keck Futures Initiative...
  • Synbio in Society webcast Synbio in Society: Toward New Forms of Collaboration? Webcast http://www.synbioproject.org/events/archive/collaboration/ Jane Calvert, Ph.D., Research Fellow at the University of Edinburgh's ESRC Innogen Centre, Member of the Synthetic Aesthetics...
  • White House Planning Policy Group   White House Planning Policy Group on Emerging Technologies   Andrew Maynard Andrew Maynard 2020 Science Posted: Apr 12, 2010 at http://ieet.org/index.php/IEET/more/maynard20100412/...
  • Designer life discussion  DESIGNER LIFE: SCOTLAND’S NEXT INDUSTRIAL REVOLUTION? Professor Ben Davis, Professor Joyce Tait, Dr Jim Haseloff and Richard Holloway Featuring renowned chemist and synthetic biology expert Prof. Ben Davis (Oxford University)...
  • Synthetic Biology and defense Pentagon turns to 'softer' sciences US defence research to focus more on biology, cybersecurity and social sciences to help win conflicts. Sharon Weinberger  Published online 14 April 2010 | Nature 464, 970 (2010) | doi:10.1038/464970a...
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