Engineering tools for Gram positive bacteria
Gram positive bacteria like Bacillus subtilis provide a number of benefits for synthetic biologists. B. subtilis is non-tranformable and naturally transformable, with an efficient system for homologous transformation. Gram positive bacteria provide the bulk of industrially important species and their architectures allow high level secretion of enzymes and other proteins. The Synthetic Biology group at the University of Cambridge is developing tools for work with B. subtilis. The pages in this section provide access to recent papers and relevant websites in the field.
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Bacterial physiology: Bacillus takes the temperature: "Nature Reviews Microbiology 8, 680 (2010). doi:10.1038/nrmicro2445 Author: Lucie Wootton Bacillus subtilis uses a ruler-like mechanism to sense temperature according to membrane thickness. (Via Nature Reviews Microbiology.)
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The unique binding mode of cellulosomal CBM4 from Clostridium thermocellum cellobiohydrolase A.: "Publication Date: 2010 Sep 17 PMID: 20654622 Authors: Alahuhta, M. - Xu, Q. - Bomble, Y. J. - Brunecky, R. - Adney, W. S. - Ding, S. Y. - Himmel, M. E. - Lunin, V. V. Journal: J Mol Biol The crystal structure of the carbohydrate-binding module (CBM) 4 Ig fused domain from the cellulosomal cellulase...
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Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis.: "Publication Date: 2010 Sep 14 PMID: 20805502 Authors: Liu, W. T. - Yang, Y. L. - Xu, Y. - Lamsa, A. - Haste, N. M. - Yang, J. Y. - Ng, J. - Gonzalez, D. - Ellermeier, C. D. - Straight, P. D. - Pevzner, P. A. - Pogliano, J. - Nizet, V. - Pogliano, K. - Dorrestein, P. C. Journal:...
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Biogenic Insecticides Decoded
ScienceDaily (Mar. 6, 2010) — In the latest issue of Science, researchers from the University of Freiburg report on their discovery of a new mode of action of insecticidal toxins from Photorhabdus luminescens, a bacterium which lives in a symbiotic relationship with nematodes.
Galleria mellonella (greater wax moth) infected with Photorhabdus...
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Vast Microbial Diversity of Carnivorous Pitcher Plant Uncovered
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Sarracenia alata flowers. (Credit: Photo by Noah Elhardt / Courtesy of Wikimedia Commons)
From ScienceDaily (Mar. 29, 2010) — The microbial ecosystem inside the carnivorous pitcher plant is vastly more diverse than previously thought, according to research published in the March 2010 issue of the...
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From: http://www.cbc.ca/technology/story/2010/03/25/tech-bacteria-create-oxygen.html
A new study of methane-munching microbes adds weight to the idea that bacteria were producing oxygen on Earth before photosynthesis evolved.
Margaret Butler of the Australian Institute for Bioengineering and Nanotechnology at the University of Queensland, and colleagues, report their study of a new kind...
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Census offers glimpse of oceans' smallest lifeforms
By Mark Kinver (http://news.bbc.co.uk/1/hi/sci/tech/8622608.stm)
Science and...
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Microbes May Be More Networked Than You Are (Wired Op-ed)
When we think of networks, we think of humans and the cables we’ve run around the world to connect our species. Figuring out how to move electrons has transformed human society, but we are not the only species on earth that lives in a wired world.
From the Fields is a periodic Wired Science op-ed series presenting...
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Bio Hacking Resources
From: http://www.kk.org/cooltools/archives/000582.php
I've been expecting tools for basement bio hacks any day now for about 20 years. They are getting real close, although most of what you can do with this stuff so far is elementary, trivial and not very useful. Still, here are a few do-it-yourself gene hacking resources finally emerging. The prime users are...
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Using imaging mass spectrometry, researchers at the University of California, San Diego have developed tools that will enable scientists to visualize how different cell populations of cells communicate. Their study shows how bacteria talk to one another – an understanding that may lead to new therapeutic discoveries for diseases ranging from cancer to diabetes and allergies.
In the paper...
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