Positive feedback of G1 cyclins ensures coherent cell cycle entry

Nature 454, 291 (2008). doi:10.1038/nature07118

Authors: Jan M. Skotheim, Stefano Di Talia, Eric D. Siggia & Frederick R. Cross

In budding yeast, Saccharomyces cerevisiae, the Start checkpoint integrates multiple internal and external signals into an all-or-none decision to enter the cell cycle. Here we show that Start behaves like a switch due to systems-level feedback in the regulatory network. In contrast to current

[From Positive feedback of G1 cyclins ensures coherent cell cycle entry]